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Ari Melnick Selected Research

Pre-B Cell Receptors

4/2016PTEN opposes negative selection and enables oncogenic transformation of pre-B cells.
3/2015Self-enforcing feedback activation between BCL6 and pre-B cell receptor signaling defines a distinct subtype of acute lymphoblastic leukemia.
8/2013BACH2 mediates negative selection and p53-dependent tumor suppression at the pre-B cell receptor checkpoint.

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Ari Melnick Research Topics

Disease

53Neoplasms (Cancer)
12/2021 - 07/2002
27Lymphoma (Lymphomas)
01/2021 - 03/2002
23B-Cell Lymphoma (Lymphoma, B Cell)
01/2022 - 12/2003
21Leukemia
11/2021 - 03/2002
18Acute Myeloid Leukemia (Acute Myelogenous Leukemia)
12/2018 - 02/2004
11Diffuse Large B-Cell Lymphoma (Lymphoma, Large Cell, Diffuse)
01/2021 - 02/2005
5Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia)
03/2015 - 03/2008
4Breast Neoplasms (Breast Cancer)
10/2022 - 05/2009
4Multiple Myeloma
10/2021 - 04/2015
4Genetic Translocation (Chromosomal Translocation)
08/2013 - 07/2002
2Inflammation (Inflammations)
12/2020 - 01/2017
2B-Cell Chronic Lymphocytic Leukemia (Chronic Lymphocytic Leukemia)
12/2017 - 05/2014
2Follicular Lymphoma (Lymphoma, Small Cleaved Cell, Follicular)
01/2017 - 10/2011
2Glioma (Gliomas)
11/2016 - 02/2012
2Genomic Instability
10/2015 - 01/2009
2Myelodysplastic Syndromes (Myelodysplastic Syndrome)
04/2014 - 10/2009
2Chondrosarcoma
09/2013 - 02/2012
2Mantle-Cell Lymphoma (Lymphoma, Mantle Cell)
08/2010 - 03/2009
2Acute Promyelocytic Leukemia
02/2004 - 03/2002
2Hematologic Neoplasms (Hematological Malignancy)
02/2004 - 07/2002
1Prostatic Neoplasms (Prostate Cancer)
10/2022
1Residual Neoplasm
01/2021
1Hypersensitivity (Allergy)
01/2019
1Anemia
03/2017
1Lung Injury
01/2017

Drug/Important Bio-Agent (IBA)

22Proteins (Proteins, Gene)FDA Link
01/2021 - 03/2002
15DNA (Deoxyribonucleic Acid)IBA
10/2022 - 01/2009
15Biological ProductsIBA
01/2021 - 03/2008
13Transcription Factors (Transcription Factor)IBA
10/2022 - 07/2002
9CytosineIBA
12/2021 - 03/2008
7Pharmaceutical PreparationsIBA
01/2021 - 06/2010
6ChromatinIBA
01/2021 - 01/2009
5Co-Repressor ProteinsIBA
01/2021 - 03/2002
5MethyltransferasesIBA
12/2019 - 01/2009
56- amino- 8- ((6- iodo- 1,3- benzodioxol- 5- yl)thio)- N- (1- methylethyl)- 9H-purine-9-propanamineIBA
11/2015 - 05/2009
4Lysine (L-Lysine)FDA Link
01/2021 - 03/2008
4Histones (Histone)IBA
01/2021 - 03/2008
4Biomarkers (Surrogate Marker)IBA
12/2018 - 11/2016
4Oncogene Proteins (Oncogene Protein)IBA
09/2011 - 02/2004
4Peptides (Polypeptides)IBA
02/2008 - 12/2004
3ChemokinesIBA
12/2020 - 03/2011
3Histone Deacetylases (Histone Deacetylase)IBA
01/2019 - 07/2002
3ibrutinibIBA
12/2017 - 11/2015
3Small Interfering RNA (siRNA)IBA
06/2017 - 04/2008
3Azacitidine (5 Azacytidine)FDA Link
01/2017 - 10/2009
3Pre-B Cell ReceptorsIBA
04/2016 - 08/2013
2hydrogen sulfite (bisulfite)IBA
01/2021 - 04/2015
2Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
12/2020 - 01/2009
2LigandsIBA
12/2020 - 08/2014
2Histone MethyltransferasesIBA
10/2020 - 07/2011
2Oxidoreductases (Dehydrogenase)IBA
01/2019 - 08/2012
2isocitric acid (isocitrate)IBA
01/2019 - 08/2012
2Mucosa-Associated Lymphoid Tissue Lymphoma Translocation 1 ProteinIBA
10/2018 - 12/2013
2EnzymesIBA
11/2017 - 12/2010
2Messenger RNA (mRNA)IBA
11/2017 - 05/2014
2Phosphoric Monoester Hydrolases (Phosphatases)IBA
04/2016 - 12/2009
2RNA (Ribonucleic Acid)IBA
02/2016 - 11/2015
2Protein Isoforms (Isoforms)IBA
11/2015 - 07/2010
2ProteomeIBA
08/2014 - 09/2011
2A-Form DNA (A-DNA)IBA
05/2014 - 01/2011
2entinostat (MS 275)IBA
04/2014 - 10/2009
2purineIBA
10/2013 - 12/2009
2Isocitrate Dehydrogenase (Isocitrate Dehydrogenase (NAD+))IBA
09/2013 - 02/2012
2alpha-hydroxyglutarateIBA
02/2012 - 12/2010
2Rituximab (Mabthera)FDA Link
10/2011 - 04/2010
2Adenosine Triphosphate (ATP)IBA
12/2009 - 02/2006
2Heat-Shock Proteins (Heat-Shock Protein)IBA
12/2009 - 05/2009
1AndrogensIBA
10/2022
15-Methylcytosine (5 Methylcytosine)IBA
12/2021
1Mechanistic Target of Rapamycin Complex 1IBA
11/2021
1Cyclin-Dependent Kinase 9IBA
01/2021
1histone H3 trimethyl Lys4IBA
01/2021
1C-Reactive ProteinIBA
12/2020
1Interleukin-1 (Interleukin 1)IBA
12/2020
1Interleukin-1 Receptors (Interleukin 1 Receptor)IBA
12/2020
1venetoclaxIBA
10/2020
1tazemetostatIBA
10/2020
1Hydroxymethyl and Formyl TransferasesIBA
01/2020
1RNA Splicing FactorsIBA
12/2019
1Arginine (L-Arginine)FDA Link
12/2019
1Enhancer RNAsIBA
01/2019
1Deoxyribonucleases (DNase)FDA Link
01/2019
1Protein-Arginine N-Methyltransferases (Methyltransferase, Protein Arginine)IBA
01/2019
1Phosphotransferases (Kinase)IBA
01/2018
1ThioureaIBA
01/2018
1Mitogen-Activated Protein Kinase Kinases (MEKs)IBA
01/2018
1CytidineIBA
01/2018
1CaspasesIBA
12/2017
1NucleotidesIBA
11/2017
16-methyladenineIBA
11/2017
1N-methyladenosineIBA
11/2017
1CytokinesIBA
01/2017
1Monocyte Chemoattractant ProteinsIBA
01/2017
1Drug CombinationsIBA
01/2017

Therapy/Procedure

30Therapeutics
10/2021 - 07/2002
6Drug Therapy (Chemotherapy)
11/2021 - 09/2008
3Ligation
07/2013 - 01/2009
2Stem Cell Transplantation
06/2010 - 06/2010
1Precision Medicine
01/2021
1Immunotherapy
01/2021